منابع مشابه
Clearance of Alzheimer's Aβ Peptide The Many Roads to Perdition
production will attenuate the formation of  amyloid and, ultimately, slow down or halt neurodegeneration. However, facilitation of A clearance carries the potential to be equally effective at lowering  amyloid burden. This minireview covers the known pathways by which Mounting evidence suggests that the low-density lipo-protein receptor-related protein (LRP) and the receptor for advanced gly...
متن کاملAβ Clearance, “hub” of Multiple Deficiencies Leading to Alzheimer Disease
(2015) Aβ clearance, " hub " of multiple deficiencies leading to Alzheimer disease. The role of the amyloid cascade in the pathogenesis of Alzheimer's disease (AD) is still the subject of passionate debates (Herrup, 2015; Musiek and Holtzman, 2015). According to quite a radical viewpoint (Herrup, 2015), the tendency to try to find a unifying etiopathogenetic pathway has so far hampered the unde...
متن کاملMechanisms of Aβ Clearance and Degradation by Glial Cells
Glial cells have a variety of functions in the brain, ranging from immune defense against external and endogenous hazardous stimuli, regulation of synaptic formation, calcium homeostasis, and metabolic support for neurons. Their dysregulation can contribute to the development of neurodegenerative disorders, including Alzheimer's disease (AD). One of the most important functions of glial cells i...
متن کاملEffect of rosiglitazone on amyloid precursor protein processing and Aβ clearance in streptozotocin-induced rat model of Alzheimer’s disease
Objective(s): Increasing evidence suggests that Alzheimer’s disease (AD) is associated with diabetes. Rosiglitazone, a peroxisome proliferator-activated receptor γ (PPAR-γ) agonist and anti-diabetic agent, may improve symptoms of AD. However, the underlying therapeutic potential of it has not been fully elucidated. Materials and Methods: Rats were divided into four groups: control group, sham o...
متن کاملSodium Chloride Increases Aβ Levels by Suppressing Aβ Clearance in Cultured Cells
Recent studies suggest that high-salt diet is associated with cognitive decline in human and mouse. The fact that genetic factors account for less than 50% cases of sporadic Alzheimer's disease (AD) highlights the important contribution of environmental factors, such as high-salt diet, in AD pathogenesis. However, whether and how high-salt diet fits the "amyloid cascade" hypothesis remains unex...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuron
سال: 2004
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2004.08.024